Proxmox vs Nutanix – Best One for Hybrid Infrastructure Management
Nov 28th, 2025 | 7 min read
Table Of Contents
- Hybrid Cloud and Virtualization with Proxmox
- Hyper-Converged Infrastructure with Nutanix
- Proxmox vs Nutanix - How They Differ?
- Running Postgres on Proxmox vs Nutanix
- Simplifying Storage for Proxmox and Nutanix with Simplyblock
- Proxmox, Nutanix, or Both - Decide on the Best Solution
- See Other Comparisons :
- Questions and answers
As organizations scale their IT infrastructures, choosing the right platform for managing workloads becomes critical. Proxmox offers a cost-effective, open-source solution for managing virtual machines and containers in hybrid cloud environments, making it ideal for smaller to medium-sized businesses.
On the other hand, Nutanix provides an enterprise-grade hyper-converged infrastructure designed to handle cloud-native applications at scale. Understanding the strengths and use cases for both platforms will help you determine which one aligns best with your business goals.
Hybrid Cloud and Virtualization with Proxmox
Proxmox is an open-source platform that combines KVM (for full virtualization) and LXC (for containers) to offer a unified solution for managing both virtual machines and containers. Its flexibility allows businesses to integrate traditional virtualized workloads with modern containerized applications in hybrid cloud environments.
With features like high availability clustering, backups, and multi-node support, Proxmox makes it easy to scale infrastructure while maintaining low operational costs. It’s an ideal choice for organizations looking for a reliable yet cost-effective solution.
🚀 Transform your Proxmox infrastructure with Simplyblock’s storage solutions.
Built for VMs and containers, our storage ensures scalable, reliable growth for hybrid cloud environments.
👉 Experience faster Proxmox deployments with Simplyblock
Key Features of Proxmox
Proxmox provides a comprehensive platform for managing both virtualized and containerized workloads.
- Supports KVM for full virtualization and LXC for lightweight container management.
- Built-in clustering and failover options ensure minimal downtime and reliability.
- Simplify backup and restore operations for both VMs and containers.
- Easily manage all your virtualized and containerized workloads via a user-friendly web interface.
Proxmox for Hybrid Cloud Environments
Proxmox shines in environments that require both virtualization and container management, making it a great choice for hybrid cloud infrastructures.
- Easily integrates with both public and private cloud environments.
- Manage both VMs and containers from a single, integrated platform.
- Dynamically allocate resources between VMs and containers based on workload demands.
- As an open-source platform, Proxmox is a low-cost solution for businesses needing flexibility and efficiency.
Scalability and Performance with Proxmox
Proxmox is designed to scale as your infrastructure grows, ensuring that performance remains high even in complex environments.
- Supports multi-node clustering for scalable infrastructure.
- Dynamic resource allocation helps ensure performance across growing workloads.
- Proxmox supports large-scale deployments with optimized performance.
- Easily add nodes and scale horizontally to accommodate expanding workloads.
Hyper-Converged Infrastructure with Nutanix
Nutanix is a leading hyper-converged infrastructure (HCI) solution that integrates compute, storage, and virtualization into a single platform. It is designed to simplify infrastructure management by combining these key elements, offering a streamlined solution for private, public, and hybrid cloud environments.
Nutanix supports cloud-native applications, VMware, and Kubernetes, making it ideal for large enterprises. With built-in automation, data protection, and disaster recovery features, Nutanix provides businesses with a comprehensive, highly available, and secure infrastructure solution.
Key Features of Nutanix
Nutanix offers a robust and scalable infrastructure platform for managing cloud-native applications and virtualized environments.
- Combines compute, storage, and virtualization in a single, integrated platform.
- Designed to support cloud-native applications, Kubernetes, and containerized workloads.
- Scalable infrastructure that supports high-performance enterprise workloads.
- Built-in automation tools for provisioning, scaling, and managing infrastructure.
Nutanix for Cloud and Hybrid Cloud Environments
Nutanix is particularly effective for enterprises that need to manage workloads across hybrid and multi-cloud environments, providing flexibility and reliability.
- Seamlessly integrates with public cloud environments, enabling a unified infrastructure.
- Supports cloud migrations and workload management across multiple cloud environments.
- Built-in disaster recovery solutions ensure data integrity and availability.
- Centralized management for both private and public cloud workloads.
Scalability and Performance with Nutanix
Nutanix is built to scale with growing infrastructure needs, providing the performance required by modern enterprise workloads.
- Easily scale compute and storage resources as needed.
- Nutanix ensures continuous uptime with built-in failover and self-healing capabilities.
- Delivers high performance for Kubernetes-driven workloads and containerized applications.
- Simplifies backup and recovery with centralized management tools.
Proxmox vs Nutanix – How They Differ?
Proxmox and Nutanix serve different roles in the infrastructure landscape. Below is a detailed breakdown to help you choose the right platform for your organization’s needs.
| Category | Proxmox | Nutanix |
| Primary Purpose | Virtual machine and container management | Hyper-converged infrastructure for cloud-native and traditional workloads |
| Technology Base | KVM for VMs, LXC for containers | Integrated compute, storage, and virtualization in a single platform |
| Ideal Use Cases | Hybrid cloud environments, virtualization | Cloud-native applications, enterprise-grade HCI |
| Deployment Models | On-premises, hybrid cloud | Private cloud, hybrid cloud, multi-cloud |
| Scalability | Scales VMs and containers | Enterprise-scale, supports large cloud-native applications |
| Storage Management | VM and container storage management | Integrated storage with data protection and disaster recovery |
| Best For | Small-to-medium enterprises, virtualization | Large enterprises, cloud-native, and HCI-focused workloads |
Running Postgres on Proxmox vs Nutanix
Postgres on Proxmox offers flexibility for both traditional VMs and containers, making it perfect for hybrid workloads. In contrast, Nutanix offers seamless integration with cloud-native applications, optimizing Postgres for scalability, high availability, and performance in enterprise environments.
If Postgres is the main workload you care about, it’s often easier to treat it as a platform rather than something you hand-roll on top of your virtualization choice. Vela is a Postgres platform by Simplyblock that runs on Kubernetes, providing high-performance PostgreSQL with built-in automation, backups, and scaling.
Simplifying Storage for Proxmox and Nutanix with Simplyblock
Simplyblock’s storage solutions integrate seamlessly with both Proxmox and Nutanix, offering a unified, high-performance solution for virtualized and cloud-native workloads.
Whether you’re managing virtual machines with Proxmox or enterprise workloads with Nutanix, Simplyblock ensures scalable, reliable, and efficient storage, helping businesses optimize their infrastructure and drive performance across both environments.
Managing Proxmox Performance with Simplyblock’s Scalable Storage
- Manage both VMs and containers with reliable storage solutions.
- Effortlessly integrates with Proxmox’s storage management.
- Provides high-throughput, low-latency storage for virtualized workloads.
- Easily scale as your Proxmox infrastructure grows.
Optimizing Nutanix with Simplyblock’s Unified Storage Solution
- Manage persistent storage for cloud-native workloads.
- Dynamically scale storage resources as Nutanix grows.
- Ensure continuous uptime with robust storage support.
- Centralized storage management across hybrid cloud environments.
Why Simplyblock is the Ideal Solution for Both Platforms
- Simplify management across VMs and cloud-native apps.
- NVMe-powered storage ensures high-speed performance.
- Easily scale storage as both platforms grow.
- One solution for managing storage across hybrid and cloud-native workloads.
Proxmox, Nutanix, or Both – Decide on the Best Solution
Choosing between Proxmox, Nutanix, or using both depends on your infrastructure needs.
- Proxmox is ideal for small-to-medium businesses needing a cost-effective hybrid cloud solution for VMs and containers.
- Nutanix suits large enterprises requiring scalability, high performance, and cloud-native infrastructure for Kubernetes workloads.
Using both platforms together can optimize traditional and cloud-native workloads, with Simplyblock providing unified storage across both. Simplyblock ensures scalable, high-performance storage for Proxmox and Nutanix, streamlining infrastructure management for diverse environments.
See Other Comparisons :
Take a look at how these platforms measure up.
Questions and answers
Proxmox is a cost-effective solution for managing virtual machines and containers, ideal for small to medium-sized businesses in hybrid cloud environments. Nutanix, on the other hand, is a fully integrated HCI solution designed for large enterprises managing cloud-native applications and workloads at scale, providing high performance and automated infrastructure management.
Nutanix is built for scalability at an enterprise level, supporting large cloud-native workloads with high availability and automated scaling. Proxmox also scales well but is typically used for smaller to medium-sized businesses with fewer resources and less complex infrastructure needs.
Yes, using Proxmox and Nutanix together can optimize both traditional and cloud-native workloads. Proxmox can handle legacy applications and virtualization, while Nutanix excels in managing large-scale, cloud-native applications. Simplyblock provides a unified storage solution that integrates seamlessly with both platforms, ensuring high-performance storage for all workloads.
Nutanix offers built-in disaster recovery and self-healing features, ensuring continuous uptime and availability, particularly for cloud-native applications. While Proxmox supports high availability clustering and backups, Nutanix’s enterprise-grade HCI provides more advanced failover and recovery capabilities, especially in large-scale environments.
Simplyblock offers scalable, high-performance storage solutions that integrate seamlessly with both Proxmox and Nutanix. For Proxmox, Simplyblock ensures efficient storage management for virtualized workloads, while for Nutanix, it provides unified storage support across hybrid cloud environments, ensuring high-speed, reliable storage for both VMs and cloud-native workloads.